Title : Developmental changes in the constitutive and inducible expression of cytochrome P450 3A2.

Pub. Date : 1997 Oct 1

PMID : 9353139






3 Functional Relationships(s)
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1 Using a CYP3A2-specific oligonucleotide and an antipeptide antibody raised against the C terminus of CYP3A2 (VINGA) it is demonstrated that metyrapone administration to adult (12 weeks old) but not immature (3 weeks old) male Sprague Dawley rats induces the hepatic expression of CYP3A2 mRNA and protein. Metyrapone cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 Using a CYP3A2-specific oligonucleotide and an antipeptide antibody raised against the C terminus of CYP3A2 (VINGA) it is demonstrated that metyrapone administration to adult (12 weeks old) but not immature (3 weeks old) male Sprague Dawley rats induces the hepatic expression of CYP3A2 mRNA and protein. Metyrapone cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
3 Using a CYP3A2-specific oligonucleotide and an antipeptide antibody raised against the C terminus of CYP3A2 (VINGA) it is demonstrated that metyrapone administration to adult (12 weeks old) but not immature (3 weeks old) male Sprague Dawley rats induces the hepatic expression of CYP3A2 mRNA and protein. Metyrapone cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus