Title : Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.

Pub. Date : 1997 Nov

PMID : 9343388






2 Functional Relationships(s)
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1 Furthermore, we demonstrate that dexamethasone, which inhibits the production of cytokines, including TNF-alpha, significantly inhibits LPS induction of JNK/SAPK activity but not that of p38, ERK1 and ERK2, or MEK3, MEK4, or MEK6. Dexamethasone mitogen-activated protein kinase 8 Homo sapiens
2 Dexamethasone also blocks the sorbitol but not anisomycin stimulation of JNK/SAPK activity. Dexamethasone mitogen-activated protein kinase 8 Homo sapiens