Title : Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis.

Pub. Date : 1997 Oct 15

PMID : 9321399






3 Functional Relationships(s)
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1 We report here that anticancer drugs such as doxorubicin lead to induction of the CD95 (APO-1/Fas) system of apoptosis and the cellular stress pathway which includes JNK/SAPKs. Doxorubicin mitogen-activated protein kinase 8 Homo sapiens
2 In contrast, JNK/SAPK activity was still inducible by doxorubicin in the NPA cells, suggesting that activation of JNK/SAPKs alone is not sufficient for induction of the CD95 system and apoptosis. Doxorubicin mitogen-activated protein kinase 8 Homo sapiens
3 In contrast, JNK/SAPK activity was still inducible by doxorubicin in the NPA cells, suggesting that activation of JNK/SAPKs alone is not sufficient for induction of the CD95 system and apoptosis. Doxorubicin mitogen-activated protein kinase 8 Homo sapiens