Pub. Date : 1997 Sep 2
PMID : 9275183
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53-independent apoptosis induced by paclitaxel through an indirect mechanism. | Paclitaxel | transformation related protein 53, pseudogene | Mus musculus |
| 2 | We tested the requirement for wild-type p53 in the response of tumor cells to treatment with paclitaxel (trade name Taxol), an antineoplastic agent that stabilizes cellular microtubules. | Paclitaxel | transformation related protein 53, pseudogene | Mus musculus |
| 3 | Although paclitaxel is broadly effective against human tumor xenografts in mice, including some known to carry p53 mutations, we found that p53-containing mouse tumor cells were significantly more sensitive to direct treatment with this drug than were p53-deficient tumor cells. | Paclitaxel | transformation related protein 53, pseudogene | Mus musculus |
| 4 | Although paclitaxel is broadly effective against human tumor xenografts in mice, including some known to carry p53 mutations, we found that p53-containing mouse tumor cells were significantly more sensitive to direct treatment with this drug than were p53-deficient tumor cells. | Paclitaxel | transformation related protein 53, pseudogene | Mus musculus |
| 5 | Although paclitaxel is broadly effective against human tumor xenografts in mice, including some known to carry p53 mutations, we found that p53-containing mouse tumor cells were significantly more sensitive to direct treatment with this drug than were p53-deficient tumor cells. | Paclitaxel | transformation related protein 53, pseudogene | Mus musculus |
| 6 | Conditioned medium from paclitaxel-treated macrophages was capable of inducing p53-independent apoptosis when applied to transformed mouse embryonic fibroblasts and was inhibitable by antibodies against TNF-alpha. | Paclitaxel | transformation related protein 53, pseudogene | Mus musculus |