Title : Effect of vitamin A deficiency on the expression of low affinity glucocorticoid binding site activity and glucocorticoid-dependent induction of CYP3A2 in rat liver.

Pub. Date : 1997 Aug 18

PMID : 9268688






5 Functional Relationships(s)
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1 Maintenance of rats on a vitamin A-deficient diet resulting in undetectable levels of plasma retinol and significant reductions in relative testes weight compared to age-matched controls leads to the loss of liver membrane-bound low affinity glucocorticoid binding site (LAGS) activity without any effects on the levels of constitutively expressed CYP3A2 protein. Vitamin A cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 Retinol acetate administration alone induces CYP3A2 protein to apparent maximal levels since dexamethasone 21-phosphate does not further increase the induction response. retinol acetate cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
3 However, CYP3A2 remains inducible to dexamethasone 21-phosphate in vitamin A-deficient rats. dexamethasone 21-phosphate cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
4 However, CYP3A2 remains inducible to dexamethasone 21-phosphate in vitamin A-deficient rats. Vitamin A cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
5 These data suggest that vitamin A status affects the expression of LAGS and CYP3A2 but that glucocorticoids regulate the induction of CYP3A2 by a mechanism(s) independent of their interaction with the LAGS. Vitamin A cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus