Pub. Date : 1997 Aug 29
PMID : 9268362
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. | ammonium ferrous sulfate | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | In the present study, we show that Fas receptor ligation or cellular treatment with synthetic C6-ceramide results in activation or phosphorylation, respectively, of the small G-protein Rac1, Jun N-terminal kinase (JNK)/p38 kinases (p38-K), and the transcription factor GADD153. | N-caproylsphingosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | In the present study, we show that Fas receptor ligation or cellular treatment with synthetic C6-ceramide results in activation or phosphorylation, respectively, of the small G-protein Rac1, Jun N-terminal kinase (JNK)/p38 kinases (p38-K), and the transcription factor GADD153. | N-caproylsphingosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | The critical function of this signaling cascade is indicated by prevention of Fas- or C6-ceramide-induced apoptosis after inhibition of Ras, Rac1, or JNK/p38-K. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |