Pub. Date : 1997 Aug 14
PMID : 9266970
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism. | Dexamethasone | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Taken together, our findings suggest that SAPK/JNK activation is not required for apoptosis in MM cells, and that there are at least two distinct apoptotic signaling pathways: (i) SAPK/JNK-associated, which is induced by IR and unaffected by IL-6; and (ii) SAPK/JNK-independent, which is induced by Dex, associated with downregulation of MAPK and p70S6K and inhibited by IL-6. | Dexamethasone | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Taken together, our findings suggest that SAPK/JNK activation is not required for apoptosis in MM cells, and that there are at least two distinct apoptotic signaling pathways: (i) SAPK/JNK-associated, which is induced by IR and unaffected by IL-6; and (ii) SAPK/JNK-independent, which is induced by Dex, associated with downregulation of MAPK and p70S6K and inhibited by IL-6. | Dexamethasone | mitogen-activated protein kinase 8 | Homo sapiens |