Pub. Date : 1997 Aug 14
PMID : 9266962
24 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | E2F transcription factor 1 | Homo sapiens |
| 2 | Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 3 | Although the proteasome inhibitors MG-132 and lactacystin markedly increased the level of expression of E2F-1 and p53, these inhibitors completely alleviated squelching by both proteins. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | E2F transcription factor 1 | Homo sapiens |
| 4 | Although the proteasome inhibitors MG-132 and lactacystin markedly increased the level of expression of E2F-1 and p53, these inhibitors completely alleviated squelching by both proteins. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 5 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 6 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | E2F transcription factor 1 | Homo sapiens |
| 7 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 8 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 9 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 10 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 11 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 12 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | E2F transcription factor 1 | Homo sapiens |
| 13 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | RB transcriptional corepressor like 1 | Homo sapiens |
| 14 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 15 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | E2F transcription factor 1 | Homo sapiens |
| 16 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 17 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 18 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 19 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 20 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |
| 21 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | E2F transcription factor 1 | Homo sapiens |
| 22 | Several observations indicate MG-132 alleviates squelching by influencing the conformation of newly synthesized p53 and E2F-1:MG-132 increased the fraction of wild type p53 bound by a monoclonal antibody which preferentially recognizes mutant conformers of p53, increased binding of hsp70 to p53 and inhibited nuclear accumulation of both p53 and E2F-1, but not the pocket protein p107. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | RB transcriptional corepressor like 1 | Homo sapiens |
| 23 | Because MG-132 and lactacycstin are highly specific inhibitors of the proteasome protease, our results suggest that the proteasome influences post-translational processes involved in proper folding and cytoplasmic clearing of E2F-1 and p53. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | E2F transcription factor 1 | Homo sapiens |
| 24 | Because MG-132 and lactacycstin are highly specific inhibitors of the proteasome protease, our results suggest that the proteasome influences post-translational processes involved in proper folding and cytoplasmic clearing of E2F-1 and p53. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | tumor protein p53 | Homo sapiens |