Pub. Date : 1997 Aug 1
PMID : 9260915
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Compelling evidence indicates that activation of the JNK/SAPK signaling pathway is obligatory for apoptosis induction by multiple cell stresses that activate the sphingomyelin cycle. | Sphingomyelins | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Moreover, ectopic expression of bcl-2 can impair apoptosis signaling by most of the cell stresses that activate the ceramide/JNK pathway. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. | N-acetylsphingosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. | N-acetylsphingosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. | N-acetylsphingosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. | N-acetylsphingosine | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 9 | Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |
| 10 | Moreover, enforced bcl-2 expression blocked the capacity of C2-ceramide to activate JNK1, indicating bcl-2 functions at the level of JNK1 or upstream of JNK1 in the ceramide/JNK pathway. | Ceramides | mitogen-activated protein kinase 8 | Homo sapiens |