Pub. Date : 1997 Aug 1
PMID : 9242457
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The c-Abl nonreceptor tyrosine kinase and the c-Jun NH2-terminal kinase (JNK/stress-activated protein kinase) are activated during the injury response to the DNA-damaging agent cisplatin. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | To identify signaling pathways activated by this detector, we investigated the effect of the loss of DNA mismatch repair function on the ability of cisplatin to activate the JNK and c-Abl kinases. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | The results demonstrate that cisplatin activates JNK kinase 3.8 +/- 0.2-fold more efficiently in DNA mismatch repair-proficient than repair-deficient cells, and that activation of c-Abl is completely absent in the DNA mismatch repair-deficient cells. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Furthermore, the results show that cisplatin-induced activation of JNK occurs through a stress-activated protein kinase/extracellular signal-regulated kinase kinase 1-independent mechanism. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | We conclude that activation of JNK and c-Abl by cisplatin is in part dependent upon the integrity of DNA mismatch repair function, suggesting that these kinases are part of the signal transduction pathway activated when mismatch repair proteins recognize cisplatin adducts in DNA. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | We conclude that activation of JNK and c-Abl by cisplatin is in part dependent upon the integrity of DNA mismatch repair function, suggesting that these kinases are part of the signal transduction pathway activated when mismatch repair proteins recognize cisplatin adducts in DNA. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |