Title : The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin.

Pub. Date : 1997 May 30

PMID : 9162025






4 Functional Relationships(s)
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1 We have studied the role of Jun/stress-activated protein kinase (JNK/SAPK) pathway in DNA repair and cisplatin resistance in T98G glioblastoma cells. Cisplatin mitogen-activated protein kinase 8 Homo sapiens
2 We show that treatment of T98G glioblastoma cells with cisplatin but not the transplatin isomer activates JNK/SAPK about 10-fold. Cisplatin mitogen-activated protein kinase 8 Homo sapiens
3 These observations indicate that the JNK/SAPK pathway is activated by cisplatin-induced DNA damage and that this response is required for DNA repair and viability following cisplatin treatment. Cisplatin mitogen-activated protein kinase 8 Homo sapiens
4 These observations indicate that the JNK/SAPK pathway is activated by cisplatin-induced DNA damage and that this response is required for DNA repair and viability following cisplatin treatment. Cisplatin mitogen-activated protein kinase 8 Homo sapiens