Pub. Date : 1997 Mar 1
PMID : 9119028
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recently, H2O2 has been reported to stimulate the activity of the mitogen-activated protein kinases (MAPKs) ERK and JNK, and the expression of the proto-oncogenes c-fos and c-jun. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | The result was positive, a maximum of stimulation being reached with 200 microM H2O2 (0.3 pmol H2O2/cell) for both ERK and JNK. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | The result was positive, a maximum of stimulation being reached with 200 microM H2O2 (0.3 pmol H2O2/cell) for both ERK and JNK. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Moreover, the stimulation by H2O2 of ERK and JNK was decreased by phospholipase A2 activity inhibitors. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | When astrocytes were incubated first with eicosatetraynoic acid, a structural analogue competing in arachidonic acid metabolism, the stimulation of JNK by H2O was also inhibited, suggesting the involvement of arachidonic acid metabolites. | ETYA | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | When astrocytes were incubated first with eicosatetraynoic acid, a structural analogue competing in arachidonic acid metabolism, the stimulation of JNK by H2O was also inhibited, suggesting the involvement of arachidonic acid metabolites. | Water | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | When astrocytes were incubated first with eicosatetraynoic acid, a structural analogue competing in arachidonic acid metabolism, the stimulation of JNK by H2O was also inhibited, suggesting the involvement of arachidonic acid metabolites. | Arachidonic Acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | Furthermore, H2O2 likely induced the expression of CL100/PAC1/MKP-1, a dual specificity phosphatase which has been implicated in ERK and JNK inactivation in the nucleus. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 9 | Finally, the prior treatment of astrocytes with MK886, a 5-lipoxygenase-activating protein inhibitor, prevented JNK from stimulation, but did not prevent thymidine incorporation from inhibition, both induced by H2O2. | MK-886 | mitogen-activated protein kinase 8 | Homo sapiens |
| 10 | These results strongly suggest an involvement of arachidonic acid and/or its metabolites in the stimulation of both ERK and JNK following the oxidative stress evoked by H2O2, which induced a cell cycle arrest probably independent of the stimulation of JNK. | Arachidonic Acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 11 | These results strongly suggest an involvement of arachidonic acid and/or its metabolites in the stimulation of both ERK and JNK following the oxidative stress evoked by H2O2, which induced a cell cycle arrest probably independent of the stimulation of JNK. | Arachidonic Acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 12 | These results strongly suggest an involvement of arachidonic acid and/or its metabolites in the stimulation of both ERK and JNK following the oxidative stress evoked by H2O2, which induced a cell cycle arrest probably independent of the stimulation of JNK. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 13 | These results strongly suggest an involvement of arachidonic acid and/or its metabolites in the stimulation of both ERK and JNK following the oxidative stress evoked by H2O2, which induced a cell cycle arrest probably independent of the stimulation of JNK. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |