Pub. Date : 1997 Feb
PMID : 9090707
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: To study the signal transduction mechanisms of tamoxifen via the activation of MAPKs, JNK and ERK in order to understand its regulation of gene expression. | Tamoxifen | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | RESULTS: TAM activated both JNK1 and ERK2 activities in a time- and dose-dependent manner in HeLa cells. | Tamoxifen | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | The activation of JNK1 was enhanced when the cells were pretreated with prooxidant H2O2. | Hydrogen Peroxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | CONCLUSIONS: These studies show that TAM activates the signal transduction kinases, JNK1 and ERK2, which may play important roles in the regulation of gene expression by TAM. | Tamoxifen | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | CONCLUSIONS: These studies show that TAM activates the signal transduction kinases, JNK1 and ERK2, which may play important roles in the regulation of gene expression by TAM. | Tamoxifen | mitogen-activated protein kinase 8 | Homo sapiens |