Title : Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation.

Pub. Date : 1997 Mar 4

PMID : 9050858






8 Functional Relationships(s)
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1 Administration of 40 mg/kg 5-fluorouracil (5-FU) to BDF-1 p53+/+ mice resulted in an increase in p53 protein at cell positions in the crypts that were also those subjected to an apoptotic cell death. Fluorouracil transformation related protein 53, pseudogene Mus musculus
2 Administration of 40 mg/kg 5-fluorouracil (5-FU) to BDF-1 p53+/+ mice resulted in an increase in p53 protein at cell positions in the crypts that were also those subjected to an apoptotic cell death. Fluorouracil transformation related protein 53, pseudogene Mus musculus
3 Administration of 40 mg/kg 5-fluorouracil (5-FU) to BDF-1 p53+/+ mice resulted in an increase in p53 protein at cell positions in the crypts that were also those subjected to an apoptotic cell death. Fluorouracil transformation related protein 53, pseudogene Mus musculus
4 Administration of 40 mg/kg 5-fluorouracil (5-FU) to BDF-1 p53+/+ mice resulted in an increase in p53 protein at cell positions in the crypts that were also those subjected to an apoptotic cell death. Fluorouracil transformation related protein 53, pseudogene Mus musculus
5 p53-Dependent cell death induced by 5-FU was only inhibited by administration of uridine. Fluorouracil transformation related protein 53, pseudogene Mus musculus
6 p53-Dependent cell death induced by 5-FU was only inhibited by administration of uridine. Uridine transformation related protein 53, pseudogene Mus musculus
7 The data show that 5-FU-induced cell death of intestinal epithelial cells is p53-dependent and suggests that changes in RNA metabolism initiate events culminating in the expression of p53. Fluorouracil transformation related protein 53, pseudogene Mus musculus
8 The data show that 5-FU-induced cell death of intestinal epithelial cells is p53-dependent and suggests that changes in RNA metabolism initiate events culminating in the expression of p53. Fluorouracil transformation related protein 53, pseudogene Mus musculus