Pub. Date : 1997 Feb 15
PMID : 9044846
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased gadd153 messenger RNA level is associated with apoptosis in human leukemic cells treated with etoposide. | Etoposide | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | We have investigated the relationships between gadd153 gene expression and apoptosis induction in four human leukemic cell lines with different sensitivities to apoptosis induced by etoposide (VP-16), a topoisomerase II inhibitor. | Etoposide | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Both gadd153 mRNA level increase and internucleosomal DNA fragmentation were inhibited by N-tosyl-L-phenylalanine chloromethylketone, a serine threonine protease inhibitor, N-acetyl-leucyl-leucyl-norleucinal, an inhibitor of calpain, N-acetylcysteine, an inhibitor of oxidative metabolism, and overexpression of Bcl-2. | Tosylphenylalanyl Chloromethyl Ketone | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | Both gadd153 mRNA level increase and internucleosomal DNA fragmentation were inhibited by N-tosyl-L-phenylalanine chloromethylketone, a serine threonine protease inhibitor, N-acetyl-leucyl-leucyl-norleucinal, an inhibitor of calpain, N-acetylcysteine, an inhibitor of oxidative metabolism, and overexpression of Bcl-2. | Acetylcysteine | DNA damage inducible transcript 3 | Homo sapiens |
| 5 | These results indicate that gadd153 gene expression increase occurs downstream of events sensitive to N-tosyl-L-phenylalanine chloromethylketone, calpain inhibitor I, and Bcl-2 and upstream of interleukin 1beta-converting enzyme-related proteases activation in leukemic cells in which treatment with VP-16 induces rapid apoptosis. | Tosylphenylalanyl Chloromethyl Ketone | DNA damage inducible transcript 3 | Homo sapiens |