Pub. Date : 1997
PMID : 8996528
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: DNA damage-inducible genes, such as gadd153, gadd45, p21 and c-jun, have previously been shown to be induced by the chemotherapeutic agent cisplatin. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | One of these genes, gadd153, has previously been reported to be differentially expressed in cisplatin-resistant cell lines and, therefore, to be a potential prognostic indicator for tumor response to cisplatin-based chemotherapy. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | One of these genes, gadd153, has previously been reported to be differentially expressed in cisplatin-resistant cell lines and, therefore, to be a potential prognostic indicator for tumor response to cisplatin-based chemotherapy. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | Induction was maximal between 24 and 48 h following exposure to the drug for all genes except c-jun which was induced by 6 h. At 24 h following cisplatin treatment the overall levels of gadd153 were less in the resistant C13* cell line than in the parental 2008 cell line, while those of gadd45 were greater in C13* than in 2008. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 5 | The more cytotoxic platinum analog, ormaplatin, also induced gadd153 and its induction was also based on cytotoxicity. | Platinum | DNA damage inducible transcript 3 | Homo sapiens |
| 6 | The more cytotoxic platinum analog, ormaplatin, also induced gadd153 and its induction was also based on cytotoxicity. | ormaplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 7 | Finally, these results strengthen previous suggestions that the expression of gadd153, and possibly other DNA damage-inducible genes, may be useful indicators of tumor response to cisplatin-based chemotherapy. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |