Pub. Date : 1996 Sep
PMID : 8910901
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity. | Dopamine | transformation related protein 53, pseudogene | Mus musculus |
| 2 | MPTP at a total dose of 96 mg/kg administered in four doses over two days produced a non-homogeneous loss of striatal dopamine transport sites and quantitatively reduced 3H-mazindol binding to similar degrees in p53-/- and wild type controls 2 and 3 weeks after starting MPTP. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | transformation related protein 53, pseudogene | Mus musculus |
| 3 | We conclude that p53 protein appears necessary for complete expression of MPTP neurotoxicity to dopamine neurons. | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | transformation related protein 53, pseudogene | Mus musculus |
| 4 | We conclude that p53 protein appears necessary for complete expression of MPTP neurotoxicity to dopamine neurons. | Dopamine | transformation related protein 53, pseudogene | Mus musculus |
| 5 | Our findings suggest that the p53 gene and other growth control genes may regulate dopamine neuronal death in PD. | Dopamine | transformation related protein 53, pseudogene | Mus musculus |