Title : Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family.

Pub. Date : 1996 Nov 1

PMID : 8910292






3 Functional Relationships(s)
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1 This prompted us to explore the possibility that kinases other than Pak might participate in signaling from GTP-binding proteins to JNK. Guanosine Triphosphate mitogen-activated protein kinase 8 Homo sapiens
2 Furthermore, we present evidence that MLK3 binds the GTP-binding proteins Cdc42 and Rac1 in vivo and that MLK3 mediates activation of MEKK-SEK-JNK kinase cascade by Rac1 and Cdc42. Guanosine Triphosphate mitogen-activated protein kinase 8 Homo sapiens
3 Taken together, these findings strongly suggest that members of the novel MLK family of highly related kinases link small GTP-binding proteins to the JNK signaling pathway. Guanosine Triphosphate mitogen-activated protein kinase 8 Homo sapiens