Title : Modulation of human platelet-activating factor receptor gene expression by protein kinase C activation.

Pub. Date : 1996 Nov 15

PMID : 8906849






2 Functional Relationships(s)
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1 PMA-mediated down-regulation could be blocked by the protein kinase C (PKC) inhibitors H-7 and calphostin C. Activation of PKC by the diacylglycerol analogue 1-oleoyl-2-acetylglycerol also resulted in down-regulation of PAF-R mRNA accumulation, whereas the inactive phorbol diester 4alpha-PMA was ineffective. Diglycerides platelet activating factor receptor Homo sapiens
2 PMA-mediated down-regulation could be blocked by the protein kinase C (PKC) inhibitors H-7 and calphostin C. Activation of PKC by the diacylglycerol analogue 1-oleoyl-2-acetylglycerol also resulted in down-regulation of PAF-R mRNA accumulation, whereas the inactive phorbol diester 4alpha-PMA was ineffective. 1-oleoyl-2-acetylglycerol platelet activating factor receptor Homo sapiens