Pub. Date : 1996 Oct
PMID : 8897914
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. | Polychlorinated Biphenyls | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |
| 2 | However, the ability of CCSP to bind small lipophilic molecules, such as steroid hormones and certain pollutants, has led to speculation that this protein may mediate the biological accumulation of potentially harmful polychlorinated biphenyl (PCB) metabolites within the lung. | Steroids | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |
| 3 | However, the ability of CCSP to bind small lipophilic molecules, such as steroid hormones and certain pollutants, has led to speculation that this protein may mediate the biological accumulation of potentially harmful polychlorinated biphenyl (PCB) metabolites within the lung. | Polychlorinated Biphenyls | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |
| 4 | However, the ability of CCSP to bind small lipophilic molecules, such as steroid hormones and certain pollutants, has led to speculation that this protein may mediate the biological accumulation of potentially harmful polychlorinated biphenyl (PCB) metabolites within the lung. | Polychlorinated Biphenyls | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |
| 5 | CCSP-deficient mice were healthy and fertile, with no gross physiological or pathological abnormalities Parenteral challenge with the PCB metabolite 4-methylsulfonyl-2,2",4",5,5"-pentachlorobiphenyl (MeSO2-PCB) demonstrated that CCSP-deficient mice no longer accumulate this class of pollutants within lung and kidney tissues. | Polychlorinated Biphenyls | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |
| 6 | CCSP-deficient mice were healthy and fertile, with no gross physiological or pathological abnormalities Parenteral challenge with the PCB metabolite 4-methylsulfonyl-2,2",4",5,5"-pentachlorobiphenyl (MeSO2-PCB) demonstrated that CCSP-deficient mice no longer accumulate this class of pollutants within lung and kidney tissues. | 4-methylsulfonyl-2,2",4",5,5"-pentachlorobiphenyl | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |
| 7 | CCSP-deficient mice were healthy and fertile, with no gross physiological or pathological abnormalities Parenteral challenge with the PCB metabolite 4-methylsulfonyl-2,2",4",5,5"-pentachlorobiphenyl (MeSO2-PCB) demonstrated that CCSP-deficient mice no longer accumulate this class of pollutants within lung and kidney tissues. | 4-methylsulfonyl-2,2",4",5,5"-pentachlorobiphenyl | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |
| 8 | These data demonstrate that CCSP is the determinant for MeSO2-PCB accumulation within mice and support the notion that bioconcentration of MeSO2-PCB pollutants occurs at sites of CCSP localization, such as the respiratory and reproductive tracts of humans. | meso2-pcb | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |
| 9 | These data demonstrate that CCSP is the determinant for MeSO2-PCB accumulation within mice and support the notion that bioconcentration of MeSO2-PCB pollutants occurs at sites of CCSP localization, such as the respiratory and reproductive tracts of humans. | meso2-pcb | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |
| 10 | These data demonstrate that CCSP is the determinant for MeSO2-PCB accumulation within mice and support the notion that bioconcentration of MeSO2-PCB pollutants occurs at sites of CCSP localization, such as the respiratory and reproductive tracts of humans. | meso2-pcb | secretoglobin, family 1A, member 1 (uteroglobin) | Mus musculus |