Title : Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human.

Pub. Date : 1996 Oct

PMID : 8894516






2 Functional Relationships(s)
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1 Ciprofloxacin and norfloxacin significantly depressed the N-demethylation of erythromycin by CYP3A4 in human microsomes and by CYP3A2 in rat microsomes. Ciprofloxacin cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 Ciprofloxacin and norfloxacin significantly depressed the N-demethylation of erythromycin by CYP3A4 in human microsomes and by CYP3A2 in rat microsomes. Norfloxacin cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus