Title : Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation.

Pub. Date : 1996 Oct

PMID : 8892753






2 Functional Relationships(s)
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1 In contrast, the gadd gene stress response to base-damaging agents, such as methylmethane sulfonate (MMS) or UV radiation, or medium depletion (starvation) occurs in all mammalian cells examined to date regardless of p53 status for both GADD45 and also GADD153, which is not IR-responsive in many lines with functional p53. gadd DNA damage inducible transcript 3 Homo sapiens
2 In contrast, the gadd gene stress response to base-damaging agents, such as methylmethane sulfonate (MMS) or UV radiation, or medium depletion (starvation) occurs in all mammalian cells examined to date regardless of p53 status for both GADD45 and also GADD153, which is not IR-responsive in many lines with functional p53. Methyl Methanesulfonate DNA damage inducible transcript 3 Homo sapiens