Title : Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils.

Pub. Date : 1996 Nov 1

PMID : 8892648






2 Functional Relationships(s)
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1 The specific binding of [3H]WEB 2086, a specific ligand for PAF-R, to eosinophils treated with 5 ng/ml of IL-5 for 12 h was significantly higher than that to untreated cells. Tritium platelet activating factor receptor Homo sapiens
2 Furthermore, we found that the PAF-induced increase in intracellular calcium ion concentration in eosinophils was markedly augmented by exposure to IL-5 for 12 h. Several lines of data suggest that the enhanced expression of PAF-R on eosinophils due to IL-5 is the cause of the augmented response to PAF. Calcium platelet activating factor receptor Homo sapiens