Pub. Date : 1996 Jul 26
PMID : 8694846
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | At this time, CYP3A2-mediated testosterone 6 beta-hydroxylation was approximately 7-fold higher in hepatocytes cultured in the presence of metyrapone than in control cells, and CYP2C11-dependent testosterone 2 alpha- and 16 alpha-hydroxylation activities were between 2 and 3-fold greater. | Testosterone | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | At this time, CYP3A2-mediated testosterone 6 beta-hydroxylation was approximately 7-fold higher in hepatocytes cultured in the presence of metyrapone than in control cells, and CYP2C11-dependent testosterone 2 alpha- and 16 alpha-hydroxylation activities were between 2 and 3-fold greater. | Metyrapone | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | At this time, CYP3A2-mediated testosterone 6 beta-hydroxylation was approximately 7-fold higher in hepatocytes cultured in the presence of metyrapone than in control cells, and CYP2C11-dependent testosterone 2 alpha- and 16 alpha-hydroxylation activities were between 2 and 3-fold greater. | Testosterone | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 4 | However, treatment of cells with metyrapone considerably elevated levels of one or more CYP3A subfamily mRNA species, as detected by a riboprobe based on the cDNA for CYP3A1 ("CYP3A1-like mRNA") that were demonstrated, by another riboprobe, not to be CYP3A2 or RNCYP3AM. | Metyrapone | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |
| 5 | The particular mechanism employed is gene-specific, whereby even the highly homologous genes CYP3A2, RL33/cDEX and, possibly, RNCYP3AM are subject to different types of regulation in the presence of metyrapone. | Metyrapone | cytochrome P450, family 3, subfamily a, polypeptide 2 | Rattus norvegicus |