Title : Interferon gamma down-regulates cytochrome P450 3A genes in primary cultures of well-differentiated rat hepatocytes.

Pub. Date : 1996 Aug

PMID : 8690406






1 Functional Relationships(s)
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1 In both control and phenobarbital-treated hepatocytes, rat recombinant IFN-gamma (33 U/mL) reduced mRNA for 3A2 and 3A1-like CYPs, as well as 3A protein and testosterone 6 beta-hydroxylase activity. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus