Pub. Date : 1996 Jan
PMID : 8554977
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153. | Paclitaxel | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | Activation of the GADD153 promoter coupled to the luciferase gene and transfected into human ovarian carcinoma 2008 cells correlated well with the increase in endogenous GADD153 mRNA after treatment with taxol but not after treatment with cDDP. | Paclitaxel | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | Activation of the GADD153 promoter coupled to the luciferase gene and transfected into human ovarian carcinoma 2008 cells correlated well with the increase in endogenous GADD153 mRNA after treatment with taxol but not after treatment with cDDP. | Paclitaxel | DNA damage inducible transcript 3 | Homo sapiens |
| 5 | Following treatment with cDDP, the increase in endogenous GADD153 mRNA was 10-fold greater than the increase in GADD153 promoter activity. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 6 | Following treatment with cDDP, the increase in endogenous GADD153 mRNA was 10-fold greater than the increase in GADD153 promoter activity. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 7 | Likewise, at equitoxic levels of exposure (IC80), cDDP produced a 5-fold greater increase in endogenous GADD153 mRNA than taxol. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 8 | The tyrosine kinase inhibitor tyrophostin B46 had no significant effect on the ability of taxol to activate the GADD153 promoter, but inhibited activation of the GADD153 promoter by cDDP in a concentration-dependent manner. | tyrophostin b46 | DNA damage inducible transcript 3 | Homo sapiens |
| 9 | The tyrosine kinase inhibitor tyrophostin B46 had no significant effect on the ability of taxol to activate the GADD153 promoter, but inhibited activation of the GADD153 promoter by cDDP in a concentration-dependent manner. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 10 | We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity. | Paclitaxel | DNA damage inducible transcript 3 | Homo sapiens |
| 11 | We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 12 | We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 13 | We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity. | alpha-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide | DNA damage inducible transcript 3 | Homo sapiens |
| 14 | We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity. | Tyrphostins | DNA damage inducible transcript 3 | Homo sapiens |
| 15 | We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |