Title : Cytochrome P450 isozymes involved in aromatic hydroxylation and side-chain N-desisopropylation of alprenolol in rat liver microsomes.

Pub. Date : 1995 Aug

PMID : 8535396






2 Functional Relationships(s)
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1 These results suggest that a CYP2D isozyme(s) is the primary enzyme in alprenolol 4-hydroxylation and N-desisopropylation in a lower substrate concentration range, and that the involvement of some male-specific P450 isozyme(s) other than CYP2C11 or CYP3A2 may cause the sex difference in the 4-hydroxylation. Alprenolol cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 These results suggest that a CYP2D isozyme(s) is the primary enzyme in alprenolol 4-hydroxylation and N-desisopropylation in a lower substrate concentration range, and that the involvement of some male-specific P450 isozyme(s) other than CYP2C11 or CYP3A2 may cause the sex difference in the 4-hydroxylation. Nitrogen cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus