Pub. Date : 1994 Jun 3
PMID : 8205621
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Full activation of the MAP kinases that phosphorylate the Jun activation domain, JNK1 and JNK2, required costimulation of T cells with either TPA and Ca2+ ionophore or antibodies to TCR and CD28. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Similar to its effect on IL-2 induction, cyclosporin A (CsA) inhibited the synergistic activation of JNK, and a competitive inhibitor of Jun phosphorylation by JNK inhibited IL-2 promoter activation. | Cyclosporine | mitogen-activated protein kinase 8 | Homo sapiens |