Pub. Date : 1994 Feb 9
PMID : 8117321
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pyrazine-induced hepatic microsomes exhibited approximately 5-fold increases in CYP2E1-catalysed metabolic activities, whereas the hepatic microsomes obtained after treatment of animals with both AS and pyrazine showed rates comparable to or less than those in control microsomes. | Pyrazines | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |
| 2 | AM or AMS suppressed constitutive and pyrazine-inducible levels of CYP2E1 similarly to AS. | Pyrazines | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |
| 3 | Time-dependent induction of CYP2E1 by pyrazine was also completely blocked by treatment of animals with AS throughout the experimental period, as evidenced by immunoblot analysis. | Pyrazines | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |
| 4 | The levels of CYP2E1 apoprotein in the hepatic microsomes isolated from animals treated with both AM and pyrazine, or with both AMS and pyrazine were comparable to those in control hepatic microsomes at days 1-3 post-treatment. | Pyrazines | cytochrome P450, family 2, subfamily e, polypeptide 1 | Rattus norvegicus |