Title : Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats.

Pub. Date : 1993 Mar-Apr

PMID : 8097709






4 Functional Relationships(s)
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1 Activities of testosterone 2 beta- and 6 beta-hydroxylases were increased by administration of clarithromycin and N-demethyl clarithromycin when these activities were measured in the presence of ferricyanide, but not significant induction was observed when measured in the absence of ferricyanide. Clarithromycin cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
2 Activities of testosterone 2 beta- and 6 beta-hydroxylases were increased by administration of clarithromycin and N-demethyl clarithromycin when these activities were measured in the presence of ferricyanide, but not significant induction was observed when measured in the absence of ferricyanide. N-Desmethyl Clarithromycin cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
3 Activities of testosterone 2 beta- and 6 beta-hydroxylases were increased by administration of clarithromycin and N-demethyl clarithromycin when these activities were measured in the presence of ferricyanide, but not significant induction was observed when measured in the absence of ferricyanide. hexacyanoferrate III cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus
4 Activities of testosterone 2 beta- and 6 beta-hydroxylases were increased by administration of clarithromycin and N-demethyl clarithromycin when these activities were measured in the presence of ferricyanide, but not significant induction was observed when measured in the absence of ferricyanide. hexacyanoferrate III cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus