Title : New targets for pyrimidine antimetabolites for the treatment of solid tumours. 2: Deoxycytidine kinase.

Pub. Date : 1994 Apr 15

PMID : 7980770






1 Functional Relationships(s)
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1 Recently, a new cytidine analogue, gemcitabine, has shown impressive activity as a single agent against several solid malignancies (ovarian cancer, non-small cell lung cancer), demonstrating that in solid tumours deoxycytidine kinase can be an important target for the activation of antimetabolites. gemcitabine deoxycytidine kinase Homo sapiens