Pub. Date : 1994 Jul
PMID : 7947390
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts. | 8-chloro-cyclic adenosine monophosphate | protein kinase cAMP-dependent type II regulatory subunit beta | Homo sapiens |
| 2 | We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. | 8-chloro-cyclic adenosine monophosphate | protein kinase cAMP-dependent type II regulatory subunit beta | Homo sapiens |
| 3 | We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. | 8-chloro-cyclic adenosine monophosphate | protein kinase cAMP-dependent type II regulatory subunit beta | Homo sapiens |
| 4 | The MT-RII beta-infected cells exhibited an increased sensitivity toward treatment with cAMP analogues, such as 8-Cl-cAMP and N6-benzyl-cAMP, as compared with the parental noninfected cells. | 8-chloro-cyclic adenosine monophosphate | protein kinase cAMP-dependent type II regulatory subunit beta | Homo sapiens |
| 5 | The MT-RII beta-infected cells exhibited an increased sensitivity toward treatment with cAMP analogues, such as 8-Cl-cAMP and N6-benzyl-cAMP, as compared with the parental noninfected cells. | 8-chloro-cyclic adenosine monophosphate | protein kinase cAMP-dependent type II regulatory subunit beta | Homo sapiens |
| 6 | These results suggest that the RII beta cAMP receptor, by binding to its ligand, cAMP, acts as a tumor suppressor protein exerting growth inhibition, differentiation, and reverse transformation. | 8-chloro-cyclic adenosine monophosphate | protein kinase cAMP-dependent type II regulatory subunit beta | Homo sapiens |