Title : Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.

Pub. Date : 1994 Jul

PMID : 7947390






6 Functional Relationships(s)
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1 Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts. 8-chloro-cyclic adenosine monophosphate protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens
2 We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. 8-chloro-cyclic adenosine monophosphate protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens
3 We have recently shown, using antisense strategy, that the RII beta regulatory subunit of cAMP-dependent protein kinase is essential for cAMP-induced growth inhibition and differentiation of HL-60 human leukemia cells. 8-chloro-cyclic adenosine monophosphate protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens
4 The MT-RII beta-infected cells exhibited an increased sensitivity toward treatment with cAMP analogues, such as 8-Cl-cAMP and N6-benzyl-cAMP, as compared with the parental noninfected cells. 8-chloro-cyclic adenosine monophosphate protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens
5 The MT-RII beta-infected cells exhibited an increased sensitivity toward treatment with cAMP analogues, such as 8-Cl-cAMP and N6-benzyl-cAMP, as compared with the parental noninfected cells. 8-chloro-cyclic adenosine monophosphate protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens
6 These results suggest that the RII beta cAMP receptor, by binding to its ligand, cAMP, acts as a tumor suppressor protein exerting growth inhibition, differentiation, and reverse transformation. 8-chloro-cyclic adenosine monophosphate protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens