Title : In vitro metabolism of dorzolamide, a novel potent carbonic anhydrase inhibitor, in rat liver microsomes.

Pub. Date : 1994 Nov-Dec

PMID : 7895610






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Antisera against rat CYP2B1, CYP2E1, and CYP3A2 suppressed dorzolamide N-deethylase activity by 52%, 43% and 46%, respectively, whereas only 18% and 15% of the activity were inhibited by anti-CYP1A1 and anti-CYP4A1 antibodies, respectively. dorzolamide cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus