Title : Transcriptional regulation of multidrug resistance in breast cancer.

Pub. Date : 1994

PMID : 7881104






3 Functional Relationships(s)
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1 The selective type I cAMP-dependent protein kinase (PKA) inhibitors, 8-Cl-cAMP and Rp8-Cl-cAMP[S] may be particularly useful for downregulating PKA-dependent MDR-associated transcription factors, and we have found these compounds to downregulate transient expression of a reporter gene under the control of several MDR1 promoter elements. 8-chloro-cyclic adenosine monophosphate programmed cell death 2 Homo sapiens
2 The selective type I cAMP-dependent protein kinase (PKA) inhibitors, 8-Cl-cAMP and Rp8-Cl-cAMP[S] may be particularly useful for downregulating PKA-dependent MDR-associated transcription factors, and we have found these compounds to downregulate transient expression of a reporter gene under the control of several MDR1 promoter elements. 8-chloro-cyclic adenosine monophosphate ATP binding cassette subfamily B member 1 Homo sapiens
3 The selective type I cAMP-dependent protein kinase (PKA) inhibitors, 8-Cl-cAMP and Rp8-Cl-cAMP[S] may be particularly useful for downregulating PKA-dependent MDR-associated transcription factors, and we have found these compounds to downregulate transient expression of a reporter gene under the control of several MDR1 promoter elements. 8-chloro-cyclic adenosine monophosphate ATP binding cassette subfamily B member 1 Homo sapiens