Pub. Date : 1994 Dec
PMID : 7773779
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos. | Proline | growth factor receptor bound protein 2 | Homo sapiens |
| 2 | GRB2 couples receptor tyrosine kinase activation to Ras signalling by interacting, through its SH3 domains, to the carboxy-terminal proline-rich regions of the guanine nucleotide exchange factor Sos. | Proline | growth factor receptor bound protein 2 | Homo sapiens |
| 3 | Here we report the synthesis and solution structure of the amino-terminal SH3 domain of GRB2 and of its more stable Ser 32 mutant. | Serine | growth factor receptor bound protein 2 | Homo sapiens |
| 4 | 1H NMR analysis of the complex between the Ser-32-GRB2-N-SH3 domain and the proline-rich peptide VPPPVPPRRR, derived from h-Sos, shows that relative to the SH3 peptide complexes described for PI3K, Fyn and Abl, the proline-rich peptide in this complex binds in the opposite orientation. | Hydrogen | growth factor receptor bound protein 2 | Homo sapiens |
| 5 | 1H NMR analysis of the complex between the Ser-32-GRB2-N-SH3 domain and the proline-rich peptide VPPPVPPRRR, derived from h-Sos, shows that relative to the SH3 peptide complexes described for PI3K, Fyn and Abl, the proline-rich peptide in this complex binds in the opposite orientation. | Serine | growth factor receptor bound protein 2 | Homo sapiens |
| 6 | 1H NMR analysis of the complex between the Ser-32-GRB2-N-SH3 domain and the proline-rich peptide VPPPVPPRRR, derived from h-Sos, shows that relative to the SH3 peptide complexes described for PI3K, Fyn and Abl, the proline-rich peptide in this complex binds in the opposite orientation. | Proline | growth factor receptor bound protein 2 | Homo sapiens |
| 7 | 1H NMR analysis of the complex between the Ser-32-GRB2-N-SH3 domain and the proline-rich peptide VPPPVPPRRR, derived from h-Sos, shows that relative to the SH3 peptide complexes described for PI3K, Fyn and Abl, the proline-rich peptide in this complex binds in the opposite orientation. | Proline | growth factor receptor bound protein 2 | Homo sapiens |