Title : MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis.

Pub. Date : 1995 May 18

PMID : 7761100






2 Functional Relationships(s)
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1 In this study, we show that the expression of both wild-type p53 and MDM2 (murine double minute 2) proteins was induced when cis-diamminedichloroplatinum (cisplatin) caused apoptosis in human glioblastoma U87-MG cells, which expressed neither wild-type p53 nor MDM2 protein prior to treatment. Cisplatin transformation related protein 53, pseudogene Mus musculus
2 In this study, we show that the expression of both wild-type p53 and MDM2 (murine double minute 2) proteins was induced when cis-diamminedichloroplatinum (cisplatin) caused apoptosis in human glioblastoma U87-MG cells, which expressed neither wild-type p53 nor MDM2 protein prior to treatment. Cisplatin transformation related protein 53, pseudogene Mus musculus