Title : The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation.

Pub. Date : 1995 Jun 15

PMID : 7759866






2 Functional Relationships(s)
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1 Here we show that, following removal of in vivo-bound IgE by lactic acid treatment, targeting of allergens to monocytes by Ag-specific IgE critically depends on Fc epsilon RI expression. Lactic Acid Fc epsilon receptor Ia Homo sapiens
2 Even more importantly, lactic acid-treated, monocyte-enriched PBMCs present allergen to T cells 100- to 1000-fold more effectively if the allergen has been targeted to Fc epsilon RI on these cells via allergen-specific IgE. Lactic Acid Fc epsilon receptor Ia Homo sapiens