Pub. Date : 1993 Aug
PMID : 7689039
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of rat liver microsomal epoxide hydrolase by thiazole and pyrazine: hydrolysis of 2-cyanoethylene oxide. | Pyrazines | epoxide hydrolase 1 | Rattus norvegicus |
| 2 | Immunoblot analyses using rabbit anti-rat mEH antibody revealed a significant increase in mEH levels in hepatic microsomes isolated from either thiazole- or pyrazine-treated animals. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |
| 3 | Immunoblot analyses using rabbit anti-rat mEH antibody revealed a significant increase in mEH levels in hepatic microsomes isolated from either thiazole- or pyrazine-treated animals. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |
| 4 | Another protein (approximately 43 kd) cross-reacting with polyclonal mEH antibody was found to be increased concomitantly following pyrazine treatment. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |
| 5 | Northern and slot blot analyses showed substantial increases in mEH mRNA following either thiazole or pyrazine treatment. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |
| 6 | Approximately 20- and 16-fold increases in mEH mRNA were also observed at 48 and 72 h respectively following treatment with pyrazine. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |
| 7 | The level of polymerase chain reaction (PCR)-amplified mEH DNA derived from poly(A)+ RNA was clearly elevated following either thiazole or pyrazine treatment relative to that from untreated animals. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |
| 8 | These kinetic data correlate well with the increases in mEH mRNA observed after administration of thiazole or pyrazine to rats. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |
| 9 | These results provide evidence that administration of thiazole or pyrazine induces mEH with a large increase in mEH mRNA, and that the induced mEH catalyzes the hydrolysis of CEO. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |
| 10 | These results provide evidence that administration of thiazole or pyrazine induces mEH with a large increase in mEH mRNA, and that the induced mEH catalyzes the hydrolysis of CEO. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |
| 11 | These results provide evidence that administration of thiazole or pyrazine induces mEH with a large increase in mEH mRNA, and that the induced mEH catalyzes the hydrolysis of CEO. | Pyrazines | epoxide hydrolase 1, microsomal | Mus musculus |