Title : RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors.

Pub. Date : 1993 Mar

PMID : 7680615






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis. Calcium C-C motif chemokine ligand 2 Homo sapiens
2 We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis. Histamine C-C motif chemokine ligand 2 Homo sapiens
3 We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis. sulfido-leukotrienes C-C motif chemokine ligand 2 Homo sapiens