Title : Frequent mutations of the p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

Pub. Date : 1995 Oct

PMID : 7586136






2 Functional Relationships(s)
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1 Frequent mutations of the p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Butylhydroxybutylnitrosamine transformation related protein 53, pseudogene Mus musculus
2 In conclusion, p53 mutations are frequent in BBN-induced mouse invasive urinary bladder tumors, at similar levels to those observed for human high-grade invasive carcinomas, and this plus their distribution suggests their possible participation in this model of urinary bladder carcinogenesis. Butylhydroxybutylnitrosamine transformation related protein 53, pseudogene Mus musculus