Title : Pyruvate neutralizes peritoneal dialysate cytotoxicity: maintained integrity and proliferation of cultured human mesothelial cells.

Pub. Date : 1995 Jul

PMID : 7564075






4 Functional Relationships(s)
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1 After exposure to the lactate-PD containing 1.36% glucose, LDH activity was increased by more than 30%, proliferation of MC was inhibited by more than 30%, and IL-1 ra production was reduced significantly when compared to pyruvate-PD and the control solution. Glucose interleukin 1 receptor antagonist Homo sapiens
2 After preincubation with 3.86% glucose containing PD, all negative effects became even more pronounced in the lactate group whereas the MC maintained their integrity, rate of proliferation and IL-1 ra release after pre-exposure to pyruvate containing PD. Methylcholanthrene interleukin 1 receptor antagonist Homo sapiens
3 These results suggest that the acute toxic effects of commercially available PD on the integrity, proliferation and IL-1 ra production of MC can be avoided by the use of sodium pyruvate instead of sodium lactate. Methylcholanthrene interleukin 1 receptor antagonist Homo sapiens
4 These results suggest that the acute toxic effects of commercially available PD on the integrity, proliferation and IL-1 ra production of MC can be avoided by the use of sodium pyruvate instead of sodium lactate. SODIUM PYRUVATE interleukin 1 receptor antagonist Homo sapiens