Pub. Date : 1994 Dec 9
PMID : 7527043
18 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 2 | Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 3 | Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 4 | Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 5 | In intact cells, the amount of Grb2/Ash coimmunoprecipitated with mutant receptors retaining tyrosines 992, 1068, 1086, 1148, or 1173 was approximately 10, 85, 55, 50, or 20% of wild-type levels, respectively. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 6 | In intact cells, the amount of Grb2/Ash coimmunoprecipitated with mutant receptors retaining tyrosines 992, 1068, 1086, 1148, or 1173 was approximately 10, 85, 55, 50, or 20% of wild-type levels, respectively. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 7 | The association of Grb2/Ash with in vitro autophosphorylated EGF receptor mutants was detectable in those retaining either tyrosines 1068 or 1086 but not in other mutants including those retaining tyrosine 1148. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 8 | The association of Grb2/Ash with in vitro autophosphorylated EGF receptor mutants was detectable in those retaining either tyrosines 1068 or 1086 but not in other mutants including those retaining tyrosine 1148. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 9 | The association of Grb2/Ash with in vitro autophosphorylated EGF receptor mutants was detectable in those retaining either tyrosines 1068 or 1086 but not in other mutants including those retaining tyrosine 1148. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 10 | The association of Grb2/Ash with in vitro autophosphorylated EGF receptor mutants was detectable in those retaining either tyrosines 1068 or 1086 but not in other mutants including those retaining tyrosine 1148. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 11 | In peptide inhibition assay, phosphorylated peptides representing tyrosines 1068 and 1086 inhibited the binding of Grb2/Ash to in vitro autophosphorylated wild-type EGF receptors, whereas the other peptides representing tyrosines 992, 1148, and 1173 failed to inhibit the binding. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 12 | In peptide inhibition assay, phosphorylated peptides representing tyrosines 1068 and 1086 inhibited the binding of Grb2/Ash to in vitro autophosphorylated wild-type EGF receptors, whereas the other peptides representing tyrosines 992, 1148, and 1173 failed to inhibit the binding. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 13 | In peptide inhibition assay, phosphorylated peptides representing tyrosines 1068 and 1086 inhibited the binding of Grb2/Ash to in vitro autophosphorylated wild-type EGF receptors, whereas the other peptides representing tyrosines 992, 1148, and 1173 failed to inhibit the binding. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 14 | In peptide inhibition assay, phosphorylated peptides representing tyrosines 1068 and 1086 inhibited the binding of Grb2/Ash to in vitro autophosphorylated wild-type EGF receptors, whereas the other peptides representing tyrosines 992, 1148, and 1173 failed to inhibit the binding. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 15 | 269, 18674-18678), these results indicate that tyrosines 1068 and 1086 of activated human EGF receptors are direct high affinity binding sites of Grb2/Ash and that tyrosine 1148 is an indirect binding site through Shc in intact cells. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 16 | 269, 18674-18678), these results indicate that tyrosines 1068 and 1086 of activated human EGF receptors are direct high affinity binding sites of Grb2/Ash and that tyrosine 1148 is an indirect binding site through Shc in intact cells. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 17 | 269, 18674-18678), these results indicate that tyrosines 1068 and 1086 of activated human EGF receptors are direct high affinity binding sites of Grb2/Ash and that tyrosine 1148 is an indirect binding site through Shc in intact cells. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |
| 18 | 269, 18674-18678), these results indicate that tyrosines 1068 and 1086 of activated human EGF receptors are direct high affinity binding sites of Grb2/Ash and that tyrosine 1148 is an indirect binding site through Shc in intact cells. | Tyrosine | growth factor receptor bound protein 2 | Homo sapiens |