Title : Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase.

Pub. Date : 1994 Sep 23

PMID : 7522233






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The Src homology 2 (SH2) domain of the adaptor protein Grb2 bound with high affinity to tyrosine-phosphorylated SHPTP2 following treatment of cells with IL-3 or GM-CSF, but not IL-4. Tyrosine growth factor receptor bound protein 2 Homo sapiens
2 This interaction was inhibited by two phosphotyrosine peptides, based on sequences within SHPTP2, which conform to the postulated consensus sequence for Grb2 SH2 recognition. phosphotyrosine peptides growth factor receptor bound protein 2 Homo sapiens