Title : Dose escalation of biweekly cyclophosphamide, doxorubicin, vincristine, and prednisolone using recombinant human granulocyte colony stimulating factor in non-Hodgkin's lymphoma.

Pub. Date : 1994 Oct 1

PMID : 7521788






3 Functional Relationships(s)
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1 The safety of increasing the dose of cyclophosphamide during biweekly CHOP then was tested. Cyclophosphamide DNA damage inducible transcript 3 Homo sapiens
2 CONCLUSIONS: The dose of cyclophosphamide in biweekly CHOP can be increased up to 1500 mg/m2 with no increase in the incidence of treatment-related early mortalities without any organ damage in younger patients. Cyclophosphamide DNA damage inducible transcript 3 Homo sapiens
3 The efficacy of this dose intensification of CHOP currently is being investigated in a multicenter prospective randomized trial using three different dose levels of cyclophosphamide. Cyclophosphamide DNA damage inducible transcript 3 Homo sapiens