Title : Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases.

Pub. Date : 1994 Mar 25

PMID : 7510706






4 Functional Relationships(s)
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1 Phosphorylation of p53 by MAP kinase occurred at two N-terminal sites, threonine residues 73 and 83. Threonine transformation related protein 53, pseudogene Mus musculus
2 Tryptic phosphopeptides of recombinant p53 phosphorylated in vitro by MAP kinase comigrated on two-dimensional maps with p53 from SV3T3 cells labeled in vivo with [32P]orthophosphate, suggesting that MAP kinase targets a site in p53 that is phosphorylated in the cell. Phosphorus-32 transformation related protein 53, pseudogene Mus musculus
3 Tryptic phosphopeptides of recombinant p53 phosphorylated in vitro by MAP kinase comigrated on two-dimensional maps with p53 from SV3T3 cells labeled in vivo with [32P]orthophosphate, suggesting that MAP kinase targets a site in p53 that is phosphorylated in the cell. Phosphates transformation related protein 53, pseudogene Mus musculus
4 Following serum stimulation of quiescent C57MG cells, two p53 kinases, which were resolved by chromatography on Mono Q, were stimulated 15-20-fold within 5 min. Mono Q transformation related protein 53, pseudogene Mus musculus