Pub. Date : 1993 Dec 15
PMID : 7505123
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Particulate beta-glucan induced IL-1Ra production from human peripheral blood mononuclear cells (PBMC) but did not stimulate IL-1 beta synthesis or gene expression in these same cells. | beta-Glucans | interleukin 1 receptor antagonist | Homo sapiens |
| 2 | However, when preincubated with PBMC, monomeric beta-glucan significantly (P < .01) reduced particulate beta-glucan induction of IL-1Ra by 40%, suggesting that crosslinking of beta-glucan receptors is required for induction of IL-1Ra. | PBMC | interleukin 1 receptor antagonist | Homo sapiens |
| 3 | However, when preincubated with PBMC, monomeric beta-glucan significantly (P < .01) reduced particulate beta-glucan induction of IL-1Ra by 40%, suggesting that crosslinking of beta-glucan receptors is required for induction of IL-1Ra. | beta-Glucans | interleukin 1 receptor antagonist | Homo sapiens |
| 4 | However, when preincubated with PBMC, monomeric beta-glucan significantly (P < .01) reduced particulate beta-glucan induction of IL-1Ra by 40%, suggesting that crosslinking of beta-glucan receptors is required for induction of IL-1Ra. | beta-Glucans | interleukin 1 receptor antagonist | Homo sapiens |
| 5 | However, when preincubated with PBMC, monomeric beta-glucan significantly (P < .01) reduced particulate beta-glucan induction of IL-1Ra by 40%, suggesting that crosslinking of beta-glucan receptors is required for induction of IL-1Ra. | beta-Glucans | interleukin 1 receptor antagonist | Homo sapiens |
| 6 | In support of this, monomeric beta-glucan immobilized on plastic surfaces stimulated IL-1Ra production. | beta-Glucans | interleukin 1 receptor antagonist | Homo sapiens |
| 7 | Vitamin D3, which increases the functional capacity of beta-glucan receptors, increased IL-1Ra production induced by particulate beta-glucan, whereas dexamethasone suppressed IL-1Ra synthesis. | Cholecalciferol | interleukin 1 receptor antagonist | Homo sapiens |
| 8 | Vitamin D3, which increases the functional capacity of beta-glucan receptors, increased IL-1Ra production induced by particulate beta-glucan, whereas dexamethasone suppressed IL-1Ra synthesis. | beta-Glucans | interleukin 1 receptor antagonist | Homo sapiens |
| 9 | Vitamin D3, which increases the functional capacity of beta-glucan receptors, increased IL-1Ra production induced by particulate beta-glucan, whereas dexamethasone suppressed IL-1Ra synthesis. | Dexamethasone | interleukin 1 receptor antagonist | Homo sapiens |