Title : [In vitro inhibition of oxidative N-demethylation with carbon disulfide].

Pub. Date : 1976 Feb

PMID : 7280






2 Functional Relationships(s)
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1 After addition of an NADPH-regenerating system to liver microsomes isolated from adult female Wistar rats, the oxidative N-demethylation of aminopyrine was measured under simultaneous exposure to CS2 by quantitatively determining the formaldehyde obtained; the resulting data were evaluated using enzyme-kinetic parameters according to Lineweaver-Burk: 1. Formaldehyde calsyntenin 2 Rattus norvegicus
2 In substrate-free control mixtures, addition of CS2 was followed by the dose-dependent formation of formaldehyde; a causal explanation is not readily available at this time. Formaldehyde calsyntenin 2 Rattus norvegicus