Title : Toxicology and pharmacology of bispyridium oximes--insight into the mechanism of action vs Soman poisoning in vivo.

Pub. Date : 1981 Mar-Apr

PMID : 6897946






3 Functional Relationships(s)
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1 Reactivation of peripheral acetylcholinesterase following Soman poisoning was more important in the beneficial therapeutic action of HI-6 than reactivation of central acetylcholinesterase. asoxime chloride acetylcholinesterase Rattus norvegicus
2 HI-6 passes the blood brain barrier as evidenced by its reactivation centrally of Sarin-inhibited acetylcholinesterase. asoxime chloride acetylcholinesterase Rattus norvegicus
3 The beneficial action of HI-6 in rats versus Soman poisoning is due to reactivation of diaphragm acetylcholinesterase. asoxime chloride acetylcholinesterase Rattus norvegicus