Title : Successful oxime therapy one hour after soman intoxication in the rat.

Pub. Date : 1978 Jun 15

PMID : 668812






2 Functional Relationships(s)
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1 The bisquaternary mono-oxime HI-6, and to a lesser extent HS-6, caused functional recovery of neuromuscular transmission in vivo and in vitro when given 60 min after soman, i.e. when the soman-cholinesterase (AChE) complex is said to be fully "aged". mono-oxime hi-6 acetylcholinesterase Rattus norvegicus
2 In experiments with isolated rat phrenic nerve-diaphragm preparations, HI-6 given 60 min after soman produced functional recovery which could be abolished by a second dose of soman, suggesting that HI-6 had reactivated the AChE and that this enzyme was then reinhibited by the second dose of soman. asoxime chloride acetylcholinesterase Rattus norvegicus