Title : Successful oxime therapy one hour after soman intoxication in the rat.

Pub. Date : 1978 Jun 15

PMID : 668812






2 Functional Relationships(s)
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1 In experiments with isolated rat phrenic nerve-diaphragm preparations, HI-6 given 60 min after soman produced functional recovery which could be abolished by a second dose of soman, suggesting that HI-6 had reactivated the AChE and that this enzyme was then reinhibited by the second dose of soman. asoxime chloride acetylcholinesterase Rattus norvegicus
2 HI-6 reactivates purified bovine erythrocyte AChE when added immediately after inhibition by soman, but does not reactivate tabun-inhibited AChE. asoxime chloride acetylcholinesterase Bos taurus